US Health Secretary Kennedy looks to fast-tracking approvals for rare disease drugsNew Foto - US Health Secretary Kennedy looks to fast-tracking approvals for rare disease drugs

By Sneha S K and Sriparna Roy (Reuters) -Health and Human Services Secretary Robert F. Kennedy Jr. said on Thursday that the U.S. drugs regulator would look for ways to fast-track approval for rare disease treatments and remove obstacles to their path to market. Kennedy made the comments at a U.S. Food and Drug Administration meeting to discuss cell and gene therapies, where panelists called for faster regulatory processes as they warned that other countries may overtake the U.S. in drug development. "We are going to continue to figure out new ways of accelerating approvals for drugs and treatments that treat rare diseases, and we're going to make this country the hub of biotechnology innovation," Kennedy said. Other members included industry executives, researchers and FDA staffers, among them Vinay Prasad, the FDA's top vaccine and biologics official. The appointment of Prasad as the head of the FDA's Center for Biologics Evaluation and Research had stoked fears that he could raise the bar for companies to get approval for new drugs, including what are known as accelerated approvals for new potential treatments of serious conditions. Prasad vowed at the meeting to rapidly make therapies available at the first sign or promise of biomedical success or action. Shares of therapy developers Sarepta, Dyne Therapeutics and Lexeo Therapeutics were trading between 1% and 3% higher in afternoon trading. U.S.-listed shares of uniQure rose 8.19% to $16.18. Panel members said that the slower regulatory process for rare disease treatments risks the United States' position as a leader in the biotechnology sector at a time when drug development in China is accelerating. "The path to approval is seen as so arduous. If firms feel there is no credible way to get new products approved here, they will simply relocate trials overseas or abandon them," panel member Carl June from University of Pennsylvania. "We cannot afford that exodus," said June. (Reporting by Sneha S K and Sriparna Roy in Bengaluru; Editing by Alan Barona)

US Health Secretary Kennedy looks to fast-tracking approvals for rare disease drugs

US Health Secretary Kennedy looks to fast-tracking approvals for rare disease drugs By Sneha S K and Sriparna Roy (Reuters) -Health and Hum...
Trump suggests Biden aides acted without then-president's knowledge -- but says he has no evidenceNew Foto - Trump suggests Biden aides acted without then-president's knowledge -- but says he has no evidence

WASHINGTON (AP) — PresidentDonald Trumpalleged Thursday that officials inJoe Biden's administration might have in effect forged their boss's signature and taken broad actions he wasn't aware of — while acknowledging he had no evidence that actually happened. Meeting in the Oval Office withGerman Chancellor Friedrich Merz, Trump repeated his long-standing allegations that the Biden White House relied on an autopen to sign presidential pardons, executive orders and other key documents, and said that cast doubt on their validity. "Essentially, whoever used the autopen was the president," Trump said. "And that is wrong. It's illegal, it's so bad and it's so disrespectful to our country." Trump went on to suggest that rogue elements within Biden's administration were faking his signature and governing without his knowledge, pushing the administration farther to the left than the president himself would have gone. "He didn't have much of an idea what was going on," Trump said. But pressed by reporters on whether he had evidence of specific items that were signed without Biden's knowledge, or by others in the administration acting illegally, Trump responded, "No. But I've uncovered, you know, the human mind." He referenced the disastrous debate performance that forced Biden to abandon his reelection bid last summer and said, "I was in a debate with the human mind and I didn't think he knew what the hell he was doing." Biden, in a statement Wednesday night, rejected any suggestion actions were taken without his knowledge, saying, "Let me be clear: I made the decisions during my presidency. I made the decisions about the pardons, executive orders, legislation, and proclamations. Any suggestion that I didn't is ridiculous and false." That came after Trump directed his administration to investigate Biden's actions as president, alleging aides masked his predecessor's "cognitive decline" and suggesting that theuse of the autopenundermines scores of his actions. The president directed Attorney General Pam Bondi and White House counsel David Warrington to handle the investigation, a significant escalation inTrump's targeting of political adversariesthat could lay the groundwork for arguments by Republicans that a range of Biden's actions as president were invalid. The Justice Department under Democratic and Republican administrations has recognized the use of an autopen to sign legislation and issue pardons for decades. Also, the president's absolute pardon power is enshrined in the U.S. Constitution. Trump's intensifying allegations against Biden reflect his fixation with his predecessor, whodefeated him in 2020. Trump never conceded the 2020 election and continues tofalsely claim it was riggedagainst him. Even on Thursday, Trump invoked his allegations about the 2020 election. Trump frequently suggests that Biden was wrong to use an autopen, a mechanical device that replicates a person's authentic signature. Trump said Thursday that he himself had used it, including as a way to save time when signing large numbers of letters from young people. Still, he argued that Biden's use of it constituted "the biggest scandal, maybe in the last hundred years in this country." Biden issued pardons for his two brothers and his sister shortly before leaving office in January, hoping to shield them from potential prosecution under Trump, who had promised retribution during last year's campaign. Other pardon recipients included members of a congressional committee that investigated the Jan. 6, 2021, riot at the U.S. Capitol. Trump often suggests that his political opponents should be investigated, and he has directed the Justice Department to look into people who have angered him over the years. They include Chris Krebs, a former cybersecurity official who disputed Trump's claims of a stolen election in 2020, and Miles Taylor, a former Department of Homeland Security official who wrote an anonymous op-ed sharply critical of the president in 2018. Meanwhile, House Oversight ChairmanJames Comerof Kentucky, a Republican, requested transcribed interviews with five Biden aides, alleging they had participated in a "cover-up" that amounted to "one of the greatest scandals in our nation's history." "These five former senior advisors were eyewitnesses to President Biden's condition and operations within the Biden White House," Comer said in a statement. "They must appear before the House Oversight Committee and provide truthful answers about President Biden's cognitive state and who was calling the shots." Comer also reiterated his call for Biden's physician, Kevin O'Connor, and other former senior White House aides to appear before the committee. He warned subpoenas would be issued this week if they refuse to schedule voluntary interviews. Rep. Brandon Gill, a freshman Republican from Texas, said "the American people didn't elect a bureaucracy to run the country." He added, "I think that the American people deserve to know the truth and they want to know the truth of what happened."

Trump suggests Biden aides acted without then-president's knowledge -- but says he has no evidence

Trump suggests Biden aides acted without then-president's knowledge -- but says he has no evidence WASHINGTON (AP) — PresidentDonald Tru...
MLB reinstates 4 players after yearlong bans for betting on baseballNew Foto - MLB reinstates 4 players after yearlong bans for betting on baseball

Major League Baseball'sone-year suspensionsfor betting on the sport ended for four players Thursday — San Diego starter Jay Groome, Athletics relief pitcher Michael Kelly, Philadelphia infielder José Rodríguez and Arizona reliever Andrew Saalfrank. The A's announced they reinstated Kelly along with left-hander T.J. McFarland, who was on the injured list. They optioned right-handers Elvis Alvarado and Justin Sterner to Triple-A Las Vegas to make room on their big league roster. Saalfrank was optioned to the Diamondbacks' rookie-level Arizona Complex League. The Padres have not announced their plans for Groome, but the Athletic reported he was not offered a contract, making him a free agent. The Phillies have not announced their intentions regarding Rodríguez. Kelly was suspended for betting on baseball while in the minor leagues, and the other three minor leaguers were penalized for betting on big league games. Each player wagered less than $1,000. Saalfrank and Rodríguez played previously in the majors. The players violated Major League Rule 21, which is posted in every clubhouse. They were handed mandatory one-year suspensions for betting on games in which they did not participate. If they had bet on any games they attended in person — even if they didn't play — they would have been banned for life. ___ AP MLB:https://apnews.com/hub/MLB

MLB reinstates 4 players after yearlong bans for betting on baseball

MLB reinstates 4 players after yearlong bans for betting on baseball Major League Baseball'sone-year suspensionsfor betting on the sport...
Caitlin Clark says she's made progress, but won't commit to return date after injury: 'I'm not going to rush my way back'New Foto - Caitlin Clark says she's made progress, but won't commit to return date after injury: 'I'm not going to rush my way back'

The Indiana Fever got some positive news Thursday. Star guard Caitlin Clark has made strong progress aftersustaining a left quad injury in May. While Clark wouldn't commit to a return date, it appears she's inching closer to a return. Clark made her first public comments Thursday since sustaining that injury. The 23-year-old said she would be reevaluated over the weekend, meaning she'll miss the team's game against the Chicago Sky on Saturday. Clark left the door open for a return ahead of the team's game against the Atlanta Dream on Tuesday, though. She is going to be reevaulated this weekend and will for sure miss Chicago.She didn't rule out returning at Atlanta on Tuesday, but also didn't promise anything."I've made a lot of progress and I feel good, but I'm not going to rush my way back if it's not worth it."https://t.co/04eZKuXBfA — Chloe Peterson (@chloepeterson67)June 5, 2025 Clark has already missed three games due to the injury, which she sustained during theteam's 90-88 lossto the New York Liberty on May 24. Clark said Thursday that she didn't know when she sustained the injury, saying adrenaline covered up her pain during the contest. Two days after that loss, theFever announced Clark's injury. In its initial injury report, the team said it expected Clark to miss two weeks due to the issue. This injury was unrelated to the one that caused Clark to miss the team's first preseason game. Clark sat out of that contest due to a left quad injury, but was able to return ahead of the team's second preseason game. The Fever have gone 1-2 in Clark's absence. After dropping the first two games without Clark, the team defeated the Washington Mystics on Tuesday, picking up its first win since Clark's injury. Clark was off to a strong start prior to the injury. In four games, she averaged 19 points, 9.3 assists and 6 rebounds. Those figures were extremely close to what Clark averaged as a rookie, when she finished fourth in the MVP voting. Kelsey Mitchell and Aliyah Boston have stepped it up on offense in Clark's absence. Both players have scored double-digit points in every game since Clark's injury. They'll look to make it four in a row when the Fever take on the Sky on Saturday.

Caitlin Clark says she's made progress, but won't commit to return date after injury: 'I’m not going to rush my way back'

Caitlin Clark says she's made progress, but won't commit to return date after injury: 'I'm not going to rush my way back...
Can Zohran Mamdani, a 33-year-old democratic socialist, become the next mayor of New York City?New Foto - Can Zohran Mamdani, a 33-year-old democratic socialist, become the next mayor of New York City?

NEW YORK (AP) — Zohran Mamdani has buzz and some momentum in New York City's mayoral race. But can a 33-year-old democratic socialist — or anyone else — beat former Gov. Andrew Cuomo in the Democratic primary? Mamdani picked up a key endorsement Thursday from U.S. Rep.Alexandria Ocasio-Cortez, who said in a statement that the state lawmaker "has demonstrated a real ability on the ground to put together a coalition of working-class New Yorkers that is strongest to lead the pack." The endorsement, made the day after thefirst Democratic debateof the campaign, is likely to help solidify Mamdani's standing as a liberal darling in the contest, now in its final three weeks. It remains to be seen whether it will help him overcome Cuomo, whose campaign juggernaut has won the backing of some of the cities biggest unions as he attempts a comeback from thesexual harassment scandalthat ended his reign as governor in 2021. Mamdani's laser-focus on lowering the cost of living in one of the world's most expensive cities has helped him climb from relative obscurity to become one of the race's leading figures. His criticisms of Israel, socialist label, and relative lack of experience could hurt him, though, with centrists. Mamdani, who would be the city's first Muslim and Indian American mayor, was born in Kampala, Uganda, before he and his family moved to New York City when he was 7. He became naturalized as an American citizen a few years after graduating from college, where he co-started his school's first Students for Justice in Palestine chapter. His mother, Mira Nair, is an award-winning filmmaker. His father, Mahmood Mamdani, is an anthropology professor at Columbia University. Zohran Mamdani was elected to the state Assembly in 2020, representing a district in Queens. His most-known legislative accomplishment was pushing through a pilot program that made a handful of city buses free for a year. His mayoral campaign has been full of big promises — free child care, free buses, a rent freeze for people living in rent-regulated apartments, new affordable housing and raising taxes on the wealthy — all packaged in well-produced social media videos. Critics say his hopeful visions get blurry when it comes to detail, and have also questioned the cost and feasibility of his proposals, many of which would need support from the state Legislature and governor. Cuomo, during Wednesday night's debate, took aim at Mamdani's relative inexperience, saying the state Assembly member has a good online presence but actually "produces nothing," adding "He's been in government 27 minutes. He's passed three bills. That's all he's done." Some Jewish voters, an important voting bloc, might be turned off by Mamdani's support of the Boycott, Divestment and Sanctions movement and his use of the term "genocide" to describe Israel's war on Gaza. Mamdani has also vowed to have Israeli Prime Minister Benjamin Netanyahu arrested if he came to the city. The International Criminal Court issued anarrest warrant for Netanyahulast year, saying he had committed war crimes by using starvation as a weapon during Israel's military campaign in Gaza. Pressed during the debate on whether he thought Israel has a right to exist as a Jewish state, Mamdani said "I believe Israel has the right to exist," but "as a state with equal rights" for people who aren't Jewish. As the June 24 primary approaches, Mamdani appears aware of another issue he and every other candidate not named Cuomo is having: name recognition. Mamdani, in a recent social media video, noted that "a third of New Yorkers still haven't heard of us," though he framed that as a positive, indicating he still has room to grow. At a recent election rally in Manhattan, Maria Walles, a 54-year-old Bronx voter, said she didn't like Cuomo or Eric Adams, the incumbent mayor who facedfederal corruption charges, then decided to skip the Democratic primary and run as an independent afterPresident Donald Trump's Justice Department abandoned that prosecution. But Walles said she wasn't quite sure about the alternative candidates. "Zo ...," she said, grasping for Mamdani's name when asked about the candidate field. As it turns out, Mamdani was at the rally, which was organized by a tenant advocacy group, and received a standing ovation for his speech. To win, Mamdani will need to expand his support beyond the city's young, progressive crowd to the more moderate voters who have been a critical factor in past elections. In an interview with The Associated Press, Mamdani said if you speak to the people directly about issues they care about, such as the sky-high cost of living, you can successfully build a coalition, regardless of "what we have been told is the politics that can succeed in this city and the ways in which we have been told how to run a campaign and who we actually have to speak to." "Often times people try to characterize New York City politics through the lens of political constituencies that they define as hard and fast. And in reality there is no ideological majority in New York City," he said.

Can Zohran Mamdani, a 33-year-old democratic socialist, become the next mayor of New York City?

Can Zohran Mamdani, a 33-year-old democratic socialist, become the next mayor of New York City? NEW YORK (AP) — Zohran Mamdani has buzz and ...

 

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